{"id":3478,"date":"2019-01-15T02:41:19","date_gmt":"2019-01-15T02:41:19","guid":{"rendered":"https:\/\/research.vnuhcm.edu.vn\/?p=3478"},"modified":"2023-06-01T02:49:40","modified_gmt":"2023-06-01T02:49:40","slug":"cartilatist-thuoc-te-bao-goc-dau-tien-cua-viet-nam","status":"publish","type":"post","link":"https:\/\/research.vnuhcm.edu.vn\/index.php\/vi\/2019\/01\/15\/cartilatist-thuoc-te-bao-goc-dau-tien-cua-viet-nam\/","title":{"rendered":"Cartilatist – thu\u1ed1c t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ea7u ti\u00ean c\u1ee7a Vi\u1ec7t Nam"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Sau g\u1ea7n 10 n\u0103m nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n, Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c, Tr\u01b0\u1eddng \u0110H Khoa h\u1ecdc T\u1ef1 nhi\u00ean \u0110HQG-HCM \u0111\u00e3 cho ra \u0111\u1eddi s\u1ea3n ph\u1ea9m Cartilatist – s\u1ea3n ph\u1ea9m d\u1ea1ng thu\u1ed1c t\u1eeb t\u1ebf b\u00e0o g\u1ed1c (thu\u1ed1c t\u1ebf b\u00e0o g\u1ed1c) \u0111\u1ea7u ti\u00ean \u1edf Vi\u1ec7t Nam.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\"\"
L\u1ed9 tr\u00ecnh nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n s\u1ea3n ph\u1ea9m Cartilatist.<\/p>

Cartilatist \u0111\u01b0\u1ee3c chuy\u1ec3n giao \u0111\u1ed9c quy\u1ec1n cho C\u00f4ng ty TNHH B\u1ec7nh vi\u1ec7n \u0110a khoa V\u1ea1n H\u1ea1nh ph\u00e1t tri\u1ec3n s\u1ea3n ph\u1ea9m, s\u1ea3n xu\u1ea5t v\u00e0 th\u01b0\u01a1ng m\u1ea1i h\u00f3a t\u1eeb th\u00e1ng 7\/2018 t\u1ea1i Vi\u1ec7t Nam v\u00e0 c\u00e1c qu\u1ed1c gia ASEAN.<\/p>

Cartilatist v\u00e0 b\u1ec7nh tho\u00e1i h\u00f3a kh\u1edbp<\/strong><\/p>

Cartilatist l\u00e0 t\u00ean c\u1ee7a m\u1ed9t s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o g\u1ed1c thu t\u1eeb m\u00f4 m\u1ee1 ng\u01b0\u1eddi, s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tho\u00e1i h\u00f3a kh\u1edbp g\u1ed1i v\u00e0 tho\u00e1i h\u00f3a c\u1ed9t s\u1ed1ng. M\u1ed7i li\u1ec1u \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c \u0111\u1ef1ng trong m\u1ed9t \u1ed1ng th\u1ee7y tinh nh\u1ecf ch\u1ee9a 5-10 tri\u1ec7u t\u1ebf b\u00e0o g\u1ed1c v\u00e0 \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n trong nhi\u1ec7t \u0111\u1ed9 t\u1eeb -40 \u0111\u1ebfn -86 \u0111\u1ed9 C.<\/p>

T\u1ebf b\u00e0o g\u1ed1c t\u1eeb m\u00f4 m\u1ee1 \u0111\u01b0\u1ee3c thu nh\u1eadp, ph\u00e2n l\u1eadp v\u00e0 t\u0103ng sinh theo m\u1ed9t quy tr\u00ecnh \u0111\u1eb7c bi\u1ec7t \u0111\u1ec3 ch\u1ecdn l\u1ef1a nh\u1eefng t\u1ebf b\u00e0o g\u1ed1c c\u00f3 \u0111\u1eb7c t\u00ednh ph\u00f9 h\u1ee3p nh\u1ea5t. Quy tr\u00ecnh t\u0103ng sinh l\u00e0 ho\u00e0n to\u00e0n t\u1ef1 \u0111\u1ed9ng trong c\u00e1c bioreactor l\u1edbn v\u1edbi s\u1ef1 ki\u1ec3m so\u00e1t nghi\u00eam ng\u1eb7t c\u00e1c \u0111i\u1ec1u ki\u1ec7n s\u1ea3n xu\u1ea5t v\u00e0 \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng \u0111\u1ec3 mang l\u1ea1i t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 s\u1eed d\u1ee5ng cao.<\/p>

B\u1ec7nh nh\u00e2n tho\u00e1i h\u00f3a kh\u1edbp g\u1ed1i hay c\u1ed9t s\u1ed1ng \u1edf c\u1ea5p \u0111\u1ed9 th\u00edch h\u1ee3p s\u1ebd \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng Cartilatist \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb.<\/p>

PGS.TS Ph\u1ea1m V\u0103n Ph\u00fac – Vi\u1ec7n tr\u01b0\u1edfng Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c cho bi\u1ebft, b\u1ec7nh l\u00fd tho\u00e1i h\u00f3a kh\u1edbp v\u00e0 tho\u00e1i h\u00f3a c\u1ed9t s\u1ed1ng l\u00e0 m\u1ed9t b\u1ec7nh l\u00fd ph\u1ed5 bi\u1ebfn tr\u00ean th\u1ebf gi\u1edbi. Ri\u00eang \u1edf M\u1ef9 c\u00f3 h\u01a1n 10% ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh b\u1ecb b\u1ec7nh n\u00e0y. \u0110\u00e2y l\u00e0 b\u1ec7nh m\u1ea1n t\u00ednh li\u00ean quan s\u1ef1 tho\u00e1i h\u00f3a s\u1ee5n, d\u1eabn \u0111\u1ebfn h\u00ecnh th\u00e0nh c\u00e1c gai x\u01b0\u01a1ng, thay \u0111\u1ed5i c\u1ea5u tr\u00fac x\u01b0\u01a1ng v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 m\u1ea5t ch\u1ee9c n\u0103ng c\u1ee7a kh\u1edbp.<\/p>

Hi\u1ec7n t\u1ea1i, tho\u00e1i h\u00f3a kh\u1edbp \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb ch\u1ee7 y\u1ebfu b\u1eb1ng thu\u1ed1c gi\u1ea3m \u0111au, hyaluronic acid, v\u00e0 neridronate. Tuy nhi\u00ean, c\u00e1ch \u0111i\u1ec1u tr\u1ecb n\u00e0y ch\u1ee7 y\u1ebfu l\u00e0m gi\u1ea3m tri\u1ec7u ch\u1ee9ng, gi\u00fap gi\u1ea3m \u0111au v\u00e0 ki\u1ec3m so\u00e1t vi\u00eam, kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ng\u0103n ch\u1eb7n hay t\u00e1i t\u1ea1o tho\u00e1i h\u00f3a kh\u1edbp.<\/p>

\u00a0<\/p>

\u201cTrong m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn kh\u00e1c, tho\u00e1i h\u00f3a kh\u1edbp \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi huy\u1ebft t\u01b0\u01a1ng gi\u00e0u ti\u1ec3u c\u1ea7u (platelet-rich plasma – PRP). Nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y c\u00e1ch l\u00e0m n\u00e0y c\u1ea3i thi\u1ec7n m\u1ed9t s\u1ed1 tri\u1ec7u ch\u1ee9ng c\u1ee7a tho\u00e1i h\u00f3a kh\u1edbp nh\u01b0ng c\u0169ng kh\u00f4ng hi\u1ec7u qu\u1ea3 sau th\u1eddi gian d\u00e0i theo d\u00f5i. Do \u0111\u00f3, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u00e3 k\u1ebft h\u1ee3p vi\u1ec7c ti\u00eam PRP v\u1edbi t\u1ebf b\u00e0o g\u1ed1c. C\u00f4ng b\u1ed1 g\u1ea7n \u0111\u00e2y cho th\u1ea5y t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 k\u1ebft h\u1ee3p v\u1edbi PRP c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n \u0111\u01b0\u1ee3c t\u1ed5n th\u01b0\u01a1ng s\u1ee5n, c\u1ea3i thi\u1ec7n c\u00e1c thang \u0111i\u1ec3m VAS so v\u1edbi vi\u1ec7c ch\u1ec9 s\u1eed d\u1ee5ng PRP. Vi\u1ec7c s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p t\u1ebf b\u00e0o g\u1ed1c v\u00e0 PRP \u0111\u01b0\u1ee3c cho l\u00e0 t\u0103ng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb b\u1edfi t\u1ebf b\u00e0o g\u1ed1c c\u00f3 th\u1ec3 bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u1ebf b\u00e0o g\u1ed1c s\u1ee5n v\u00e0 \u0111\u00f3ng g\u00f3p quan tr\u1ecdng v\u00e0o qu\u00e1 tr\u00ecnh \u1ee9c ch\u1ebf vi\u00eam kh\u1edbp\u201d – PGS.TS Ph\u1ea1m V\u0103n Ph\u00fac nh\u1ea5n m\u1ea1nh.<\/p>

\u00a0<\/p>

M\u1eb7c d\u00f9 t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u1edf d\u1ea1ng l\u00e0m gi\u00e0u hay tinh s\u1ea1ch c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb tho\u00e1i h\u00f3a kh\u1edbp hi\u1ec7u qu\u1ea3 nh\u01b0ng li\u1ec7u ph\u00e1p n\u00e0y v\u1eabn c\u00f2n h\u1ea1n ch\u1ebf: hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb kh\u00f4ng \u1ed5n \u0111\u1ecbnh, ch\u1ea5t l\u01b0\u1ee3ng t\u1ebf b\u00e0o g\u1ed1c gi\u1ea3m m\u1ea1nh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i hay m\u1eafc c\u00e1c b\u1ec7nh m\u1ea1n t\u00ednh, chi ph\u00ed \u0111i\u1ec1u tr\u1ecb cao.<\/p>

\u00a0<\/p>

\"\"
C\u00e1c nghi\u00ean c\u1ee9u vi\u00ean l\u00e0m vi\u1ec7c t\u1ea1i Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c. \u1ea2nh: Minh Ch\u00e2u<\/strong><\/p>

B\u1eaft k\u1ecbp xu th\u1ebf qu\u1ed1c t\u1ebf<\/strong><\/p>

\u0110\u1ec3 gi\u1ea3i quy\u1ebft nh\u1eefng khuy\u1ebft \u0111i\u1ec3m tr\u00ean, li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c off-the-shelf \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n, mang l\u1ea1i nhi\u1ec1u \u01b0u \u0111i\u1ec3m nh\u01b0: t\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c ch\u1ecdn \u0111\u1ec3 s\u1ea3n xu\u1ea5t l\u00e0 lo\u1ea1i t\u1ed1t, kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o t\u1ebf b\u00e0o g\u1ed1c c\u1ee7a b\u1ec7nh nh\u00e2n, vi\u1ec7c s\u1ea3n xu\u1ea5t \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t ch\u1eb7t ch\u1ebd ch\u1ea5t l\u01b0\u1ee3ng theo c\u00e1c h\u01b0\u1edbng d\u1eabn nh\u01b0 GMP-WHO, gi\u00e1 th\u00e0nh gi\u1ea3m do s\u1ea3n xu\u1ea5t h\u00e0ng lo\u1ea1t.<\/p>

S\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o g\u1ed1c off-the-shelf \u0111\u1ea7u ti\u00ean tr\u00ean th\u1ebf gi\u1edbi \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh t\u1ea1i H\u00e0n Qu\u1ed1c v\u1edbi t\u00ean bi\u1ec7t d\u01b0\u1ee3c l\u00e0 Cartistem v\u00e0o n\u0103m 2012. Cartistem l\u00e0 m\u1ed9t thu\u1ed1c t\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t v\u1edbi th\u00e0nh ph\u1ea7n ho\u1ea1t t\u00ednh l\u00e0 t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 thu t\u1eeb m\u00e1u d\u00e2y r\u1ed1n ng\u01b0\u1eddi. S\u1ea3n xu\u1ea5t v\u1edbi quy m\u00f4 c\u00f4ng nghi\u1ec7p, theo h\u01b0\u1edbng d\u1eabn GMP-WHO, ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c gi\u1eefa c\u00e1c m\u1ebd \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t ch\u1eb7t ch\u1ebd; do \u0111\u00f3 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a Cartistem \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 t\u1ed1t.<\/p>

Nh\u1eefng thu\u1eadn l\u1ee3i v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 ch\u1ea5t l\u01b0\u1ee3ng s\u1ea3n ph\u1ea9m c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t \u0111\u00e3 gi\u00fap h\u01b0\u1edbng s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o g\u1ed1c off-the-shelf ph\u00e1t tri\u1ec3n nhanh. Sau 5 n\u0103m, t\u1eeb n\u0103m 2012 \u0111\u1ebfn n\u0103m 2017 \u0111\u00e3 c\u00f3 6 s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o g\u1ed1c off-the-shelf \u0111\u01b0\u1ee3c th\u01b0\u01a1ng m\u1ea1i h\u00f3a tr\u00ean th\u1ecb tr\u01b0\u1eddng \u1edf nhi\u1ec1u qu\u1ed1c gia nh\u01b0 Cartistem, Prochymal, HS Temcell, Darvadstrocel, Osteocel plus, Trinity Evolution.<\/p>

G\u1ea7n \u0111\u00e2y, s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o g\u1ed1c off-the-shelf t\u1eeb t\u1ebf b\u00e0o g\u1ed1c m\u00f4 m\u1ee1 v\u1edbi t\u00ean bi\u1ec7t d\u01b0\u1ee3c l\u00e0 Allojoin do T\u1eadp \u0111o\u00e0n Cellular Biomedicine (M\u1ef9) \u0111\u00e3 \u0111\u01b0a v\u00e0o th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u1ea1t k\u1ebft qu\u1ea3 kh\u1ea3 quan. Sau 48 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb v\u1edbi Allojoin, d\u1eef li\u1ec7u t\u1eeb 22 b\u1ec7nh nh\u00e2n cho th\u1ea5y Allojoin an to\u00e0n v\u00e0 c\u00f3 nh\u1eefng d\u1ea5u hi\u1ec7u ban \u0111\u1ea7u v\u1ec1 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb t\u1ed1t trong vi\u1ec7c ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh h\u01b0 h\u1ecfng s\u1ee5n. Thang \u0111i\u1ec3m WOMAC gi\u1ea3m m\u1ea1nh sau 12 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb v\u00e0 li\u00ean t\u1ee5c gi\u1ea3m \u0111\u1ebfn 48 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb. S\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt MRI 3D \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 s\u1ee5n kh\u1edbp sau 48 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb, cho th\u1ea5y th\u1ec3 t\u00edch s\u1ee5n \u0111\u00e3 t\u0103ng so v\u1edbi ch\u01b0a \u0111i\u1ec1u tr\u1ecb (tu\u1ea7n 0) v\u00e0 so v\u1edbi qu\u00e1 tr\u00ecnh tho\u00e1i h\u00f3a s\u1ee5n t\u1ef1 nhi\u00ean do tu\u1ed5i.<\/p>

Cartilatist l\u00e0 m\u1ed9t trong nh\u1eefng s\u1ea3n ph\u1ea9m t\u1ebf b\u00e0o g\u1ed1c off-the-shelf. \u0110i\u1ec1u \u0111\u00f3 cho th\u1ea5y Vi\u1ec7n T\u1ebf b\u00e0o g\u1ed1c \u0111\u00e3 b\u1eaft k\u1ecbp xu h\u01b0\u1edbng th\u1ebf gi\u1edbi.<\/p>

\u00a0<\/p>

\u0110\u1ea0T \u0110\u1ea0T<\/strong> (B\u1ea3n tin \u0110HQG-HCM s\u1ed1 191-192<\/a>)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t